What is the reference population and source population? ii) Is there any selection bias? iii) If yes does this threaten the external validity of the study?

Epidemiology Critical appraisal
Order Description
EPIDemiology Critical appraisal
Marked Assignment 3 -A 1000 1500 word limit exists for the submission; work beyond this restriction will not be read.
Please read the following article:
Randomized Trial of Pulsed Corticosteroid Therapy for Primary Treatment of Kawasaki Disease.
Jane W. Newburger M.D. M.P.H. Lynn A. Sleeper Sc.D. Brian W. McCrindle M.D. M.P.H. L. LuAnn Minich M.D. Welton Gersony M.D. Victoria L. Vetter M.D. Andrew M. Atz M.D. Jennifer S. Li M.D. Masato Takahashi M.D. Annette L. Baker M.S.N. P.N.P. Steven D. Colan M.D. Paul D. Mitchell M.S. Gloria L. Klein M.S. R.D.
and Robert P. Sundel M.D.
Published in The new England journal of medicine 356;7 February 15 2007 pp 663-675 www.nejm.org
Submit a formal written critical appraisal of the article by Newburger J W et al. using the following questions:
1.i) What is the research question? ii) Is it concerned with the impact of an intervention causality or determining the magnitude of a health problem?
2.i) What is the study type? ii) Is the study type appropriate to the research question?
3.i) What is the reference population and source population? ii) Is there any selection bias? iii) If yes does this threaten the external validity of the study?
4.i) Was the assignment of patients to treatments randomised? ii) Do you think the randomisation process was adequate?
5.Was blinding done in this study? If yes who were blinded?
6.What are the outcome measures and how are they measured?
7.i)Are statistical tests considered? ii)Were the tests appropriate for the data? iii)Were patients analysed in the groups to which they were randomised? iv)Do the conclusions drawn follow logically from the results of the analyses?
8.Are the results clinically or socially significant? Was the sample size adequate to detect a clinically or socially significant result?
9.What conclusions did the authors reach about the study questions? Do you accept the results of this study?

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